About
I am currently a Postdoctoral Associate in the Department of Statistics and Data Science at Yale University, working in the lab of Professor Zhou Xiang. My research aims to contribute to significant advancements in the field while deepening our understanding of biological complexities.
I graduated from the College of Pharmaceutical Sciences at Zhejiang University, where I completed my PhD under the supervision of Professor Fan Xiaohui. My research interests lie in utilizing computational tools to explore the intricate dynamics of complex physiological structures, disease progression, and multifaceted drug intervention patterns. Specifically, I focus on information mining within single-cell RNA-seq datasets, the integration of single-cell multi-omics data, and the innovative development of spatial omics analysis tools.
In addition to my research pursuits, I have a passion for literature, film, and rock music, which I believe enriches my perspective as a researcher.
Selected Publications
View All →Spatial integration of multi-omics single-cell data with SIMO
Penghui Yang, Kaiyu Jin, Yue Yao, Lijun Jin, Xin Shao, Chengyu Li, Xiaoyan Lu, Xiaohui Fan
Nature Communications
SIMO integrates spatial and multi-omics single-cell data to reveal the spatial organization of complex biological systems.
Revealing spatial multimodal heterogeneity in tissues with SpaTrio
Penghui Yang†, Lijun Jin†, Jie Liao†, Kaiyu Jin, Xin Shao, Chengyu Li, Jingyang Qian, Junyun Cheng, Dingyi Yu, Rongfang Guo, Xiao Xu, Xiaoyan Lu, Xiaohui Fan
Cell Genomics
SpaTrio reveals the spatial multimodal heterogeneity in tissues by integrating spatial transcriptomics with single-cell multi-omics data.
Single-cell RNA sequencing reveals the temporal diversity and dynamics of cardiac immunity after myocardial infarction
Kaiyu Jin†, Shan Gao†, Penghui Yang†, Rongfang Guo, Dan Li, Yunsha Zhang, Xiaoyan Lu, Guanwei Fan, Xiaohui Fan
Small Methods
Single-cell RNA sequencing reveals the dynamic changes of cardiac immune cells after myocardial infarction, providing insights into cardiac immunity and potential therapeutic targets.
Revealing the Transcriptional Heterogeneity of Organ-Specific Metastasis in Human Gastric Cancer Using Single-cell RNA Sequencing
Haiping Jiang†, Dingyi Yu†, Penghui Yang†, Rongfang Guo, Mei Kong, Yuan Gao, Xiongfei Yu, Xiaoyan Lu, Xiaohui Fan
Clinical and Translational Medicine
Single-cell RNA sequencing reveals transcriptional heterogeneity underlying organ-specific metastasis patterns in gastric cancer. (Open Science ExcelLent Author Program)
Modern research on Chinese medicine based on single-cell omics: technologies and strategies
Penghui Yang, Lijun Jin, Jie Liao, Xin Shao, Lu Li, Xiaoyan Lu, Xiaohui Fan
China Journal of Chinese Materia Medica
A comprehensive review of single-cell omics technologies and their applications in modern Chinese medicine research. (Cover Article)
News
Joined Yale University as a Postdoctoral Associate in the Department of Statistics and Data Science.
Our paper on SIMO for spatial integration of multi-omics single-cell data is published in Nature Communications.
Joined University of Michigan as a Postdoctoral Associate in the Department of Computational Medicine and Bioinformatics.
Our paper on SpaTrio for revealing spatial multimodal heterogeneity in tissues is published in Cell Genomics.